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HelpOrder Code RBPG Rubella Antibodies, IgG, Serum
Additional Codes
Epic Order ID LAB9378IA
Previous Epic Order ID IMO66
Reporting Name
Rubella Ab, IgG, SUseful For
Determining immune status to the rubella virus
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Instructions: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
Vaccinated: Positive (≥1.0 AI)
Unvaccinated: Negative (≤0.7 AI)
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86762
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RBPG | Rubella Ab, IgG, S | 5334-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| RBG | Rubella Ab, IgG, S | 40667-8 |
| DEXG2 | Rubella IgG Antibody Index | 5334-8 |
Clinical Information
Rubella (German or 3-day measles) is a member of the Togavirus family, and humans remain the only natural host for this virus. Transmission is typically through inhalation of infectious aerosolized respiratory droplets, and the incubation period following exposure can range from 12 to 23 days.(1) Infection is generally mild, self-limited, and characterized by a maculopapular rash beginning on the face and spreading to the trunk and extremities, as well as fever, malaise, and lymphadenopathy.(2)
Primary in utero rubella infections can lead to severe sequelae for the fetus, particularly if infection occurs within the first 4 months of gestation. Congenital rubella syndrome is often associated with hearing loss and cardiovascular and ocular defects.(3)
The United States 2-dose measles, mumps, rubella vaccination program, which calls for vaccination of all children, leads to seroconversion in 95% of children following the first dose.(1) A total of 4 cases of rubella were reported to the Centers for Disease Control and Prevention in 2011 without any cases of congenital rubella syndrome.(4) Due to the success of the national vaccination program, rubella is no longer considered endemic in the United States (www.cdc.gov/rubella). However, immunity may wane with age as approximately 80% to 90% of adults will show serologic evidence of immunity to rubella.
Clinical Reference
1. AAP Committee on Infectious Diseases: Rubella. In: Pickering LK, Baker CJ, Kimberlin DW, eds. Red Book. 2012 Report of the Committee on 1. AAP Committee on Infectious Diseases: Rubella. In: Pickering LK, Baker CJ, Kimberlin DW, eds. Red Book. 2012 Report of the Committee on Infectious Diseases. 29th ed. American Academy of Pediatrics; 2012
2. Best JM: Rubella. Semin Fetal Neonatal Med. 2007;12(3):182. doi:10.1016/j.siny.2007.01.017
3. Duszak RS: Congenital rubella syndrome-major review. Optometry. 2009;80(1):36. doi:10.1016/j.optm.2008.03.006
4. Notifiable Diseases and Mortality Tables. MMWR Morb Mortal Wkly Rep. 2016;65(3):ND-38
Report Available
Same day/1 to 3 daysReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
| Heat-inactivated specimen | Reject |
Method Name
Multiplex Flow Immunoassay (MFI)
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.